The recognized effect of these PTMs on ATXN2’s purpose and SCA2 pathogenesis stays limited. In other polyQ disorders, many studies suggested that proteolytic cleavage of polyQ proteins could Enjoy a vital purpose in pathogenesis [36, forty five]. Aligned with this particular thought, the existence of the enriched 42 kDa fragment within https://wesleyg554ufq7.pennywiki.com/user