Should you overlook a dose, take it when you could. If it is almost time in your next dose, just take only that dose. Do not acquire double or more doses. Nonabsorbed ursodiol passes in the colon where it is mostly seven-dehydroxylated to lithocholic acid. Some ursodiol is epimerized https://www.youtube.com/watch?v=A07qHOeWON8